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21 Night Cruises

Cruises for 21 Nights

Find the best 21-night cruise on your budget and book your unforgettable vacation today. Here you will find amazing 21-nights cruise trips around the year. Discover a wide selection of itineraries, ships, and cruise lines for your 21-nights getaway. Whether you seek a family cruise or an adult-only retreat, book now on CruiseBooking.com for an unforgettable experience.

421 Itineraries Found
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21 Nights | Transatlantic | MSC Cruises | MSC Seaside

21 Nights | Transatlantic | MSC Cruises | MSC Seaside
MSC Cruises

MSC Seaside

Civitavecchia (Rome) Miami

21 Nights
Civitavecchia (Rome) | Palermo | Barcelona | Valencia | Cadiz | Santa Cruz de Tenerife | Barbados (Bridgetown) | St George's | San Juan | Miami **

Cruise Deals from Civitavecchia (Rome) to Miami

Lowest Rate*
  • Interior $709.00
  • Oceanview $949.00
  • Balcony $1,199.00
  • Suite $2,179.00
From $709.00* $33.76 / night(s)

21 Nights | Europe | MSC Cruises | MSC Grandiosa

21 Nights | Europe | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Genoa Santos

21 Nights
Genoa | Marseille | Barcelona | Malaga | Funchal | Santa Cruz de Tenerife | Maceio | Salvador | Rio De Janeiro | Illhabela | Santos **

Cruise Deals from Genoa to Santos

Lowest Rate*
  • Interior $919.00
  • Oceanview $1,409.00
  • Balcony $1,899.00
  • Suite $8,389.00
From $919.00* $43.76 / night(s)

21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa

21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Rio De Janeiro Civitavecchia (Rome)

21 Nights
Rio De Janeiro | Buzios | Salvador | Maceio | Las Palmas | Arrecifes | TNG | Malaga | Valencia | Marseille | Genoa | Civitavecchia (Rome) **

Cruise Deals from Rio De Janeiro to Civitavecchia (Rome)

Lowest Rate*
  • Interior $1,059.00
  • Oceanview $1,549.00
  • Balcony $2,039.00
  • Suite $4,989.00
From $1,059.00* $50.43 / night(s)

21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa

21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Santos Genoa

21 Nights
Santos | Rio De Janeiro | Buzios | Salvador | Maceio | Las Palmas | Arrecifes | TNG | Malaga | Valencia | Marseille | Genoa **

Cruise Deals from Santos to Genoa

Lowest Rate*
  • Interior $1,059.00
  • Oceanview $1,549.00
  • Balcony $2,039.00
  • Suite $4,169.00
From $1,059.00* $50.43 / night(s)

21 Nights | Caribbean Eastern | MSC Cruises | MSC Meraviglia

21 Nights | Caribbean Eastern | MSC Cruises | MSC Meraviglia
MSC Cruises

MSC Meraviglia

New York City New York City

21 Nights
New York City | POP | San Juan | St Thomas (Charlotte Amalie) | St Maarten (Philipsburg) | St. Johns | New York City | POP | San Juan | St Thomas (Charlotte Amalie) | St Maarten (Philipsburg) | New York City **

Cruise Deals from New York City

Lowest Rate*
  • Interior $1,091.55
  • Oceanview $1,395.55
  • Balcony $1,745.10
  • Suite $4,778.10
From $1,091.55* $51.98 / night(s)

FAQs for 21 Night Cruises

The cost of a 21-night cruise with a family can vary depending on various factors such as cruise line, destination, cabin type, and amenities. Prices can range from a few thousand dollars to several tens of thousands of dollars.

The benefits of doing a 21-nights cruise trip are extensive exploration, relaxation and entertainment, an all-inclusive experience, a family-friendly atmosphere, and unpack once and visit multiple destinations.

When it comes to destinations for a 21-night cruise, there are numerous options. However, one suggestion for an enjoyable 21-night cruise could be a Mediterranean itinerary. This region offers a diverse mix of historical sites, stunning landscapes, and vibrant cultures. You can visit iconic cities like Barcelona, Rome, Athens, and Istanbul, explore picturesque islands such as Santorini and Mykonos, and experience the charm of lesser-known ports. The Mediterranean provides a perfect blend of history, culture, and natural beauty that can make a 21-night cruise truly memorable.
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